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1

Discovery and structure-guided drug design of inhibitors of 11β-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold

Franck Lepifre, Serge Christmann-Franck, Didier Roche, Caroline Leriche, Denis Carniato, Christine Charon, Sophie Bozec, Liliane Doare, Fabien Schmidlin, Marc Lecomte, Eric Valeur

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.30 MB

english, 2009

2

Discovery and structure–activity relationships of pentanedioic acid diamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type I

Didier Roche, Denis Carniato, Caroline Leriche, Franck Lepifre, Serge Christmann-Franck, Ulrich Graedler, Christine Charon, Sophie Bozec, Liliane Doare, Fabien Schmidlin, Marc Lecomte, Eric Valeur

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.38 MB

english, 2009

3

Glucocorticoids increase bradykinin B2 receptor gene transcription in cultured guinea-pig tracheal smooth muscle cells

Didier Scherrer, Fabien Schmidlin, El-Bdaoui Haddad, Olivier Kassel, Yves Landry, J.-P. Gies

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1999

Language:

english

File:

PDF, 223 KB

english, 1999

4

OXIDATIVE STRESS IS AN IMPORTANT COMPONENT OF AIRWAY INFLAMMATION IN MICE EXPOSED TO CIGARETTE SMOKE OR LIPOPOLYSACCHARIDE

Vincent Lagente, Jean-Michel Planquois, Olivier Leclerc, Fabien Schmidlin, Claude P Bertrand

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

5

Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors

Laurent Daeffler, Fabien Schmidlin, Jean-Pierre Gies, Yves Landry

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 218 KB

english, 1999

6

Evidence for in vitro expression of B1 receptor in the mouse trachea and urinary bladder

Marcello Trevisani, Fabien Schmidlin, Michele Tognetto, Frans P Nijkamp, Jean-Pierre Gies, Nelly Frossard, Silvia Amadesi, Gert Folkerts, Pierangelo Geppetti

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 275 KB

english, 1999

7

Glucocorticoids inhibit the bradykinin B2 receptor increase induced by interleukin-1β in human bronchial smooth muscle cells

Fabien Schmidlin, Didier Scherrer, Yves Landry, Jean-Pierre Gies

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 165 KB

english, 1998

8

Dynamin, B-arrestin and Rab5a mediated trafficking and signaling of the neurokinin 1 receptor (NK-1R)

Fabien Schmidlin, Kathryn A. Defea, Olivier Dery, Michelle Lovett, Zachary D. Vaughn, Eileen F. Grady, Nigel W. Bunnett

Journal:

Regulatory Peptides

Year:

2000

Language:

english

File:

PDF, 131 KB

english, 2000

9

Heterologous regulation of signaling and trafficking of the neurokinin-1 and neurokinin-3 receptors

Olivier Déry, Eileen F. Grady, Fabien Schmidlin, Michelle Lovett, Zackary D. Vaughn, Nigel W. Bunnett

Journal:

Regulatory Peptides

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

10

Protease-activated receptors: how proteases signal to cells

Fabien Schmidlin, Nigel W Bunnett

Journal:

Current Opinion in Pharmacology

Year:

2001

Language:

english

File:

PDF, 383 KB

english, 2001

11

Rab5a and dynamin GTPases mediate substance P (SP)-induced trafficking of the neurokinin-1 receptor (NK-1R)

Fabien Schmidlin, Olivier Dery, Michelle Lovett, Zackary D. Vaughn, DeFea Katherine, Grady F. Eileen, Nigel W. Bunnett

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

12

Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro

Marcello Trevisani, Silvia Amadesi, Fabien Schmidlin, Maria T Poblete, Elisabetta Bardella, Barbara Maggiore, Selena Harrison, Carlos D Figueroa, Michele Tognetto, Giuseppe Navarra, Alessandro Turini,

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 418 KB

english, 2003

13

Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro

Roberto De Giorgio, Marcello Trevisani, Silvia Amadesi, Fabien Schmidlin, Maria Poblete, Selena Harrison, Carlos Figueroa, Michele Tognetto, Giovanni Barbara, Vincenzo Stanghellini, Giuseppe Navarra,

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 181 KB

english, 2003

14

IL-1β modulate bradykinin receptors in human bronchial smooth muscle cells in culture

Schmidlin Fabien, Scherrer Didier, Yves Landry, Gies Jean-Pierre

Journal:

Toxicology Letters

Year:

1996

Language:

english

File:

PDF, 244 KB

english, 1996

15

Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I

Valeur, Eric, Christmann-Franck, Serge, Lepifre, Franck, Carniato, Denis, Cravo, Daniel, Charon, Christine, Bozec, Sophie, Musil, Djordje, Hillertz, Per, Doare, Liliane, Schmidlin, Fabien, Lecomte, Ma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 5.00 MB

english, 2012

16

Evidence of estrone-sulfate uptake modification in young and middle-aged rat prostate

Giton, Frank, Sirab, Nanor, Franck, Grégory, Gervais, Marianne, Schmidlin, Fabien, Ali, Tauhid, Allory, Yves, Taille, Alexandre de la, Vacherot, Francis, Loric, Sylvain, Fiet, Jean

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.09 MB

english, 2015

17

Expression and Function of Proteinase-activated Receptor 2 in Human Bronchial Smooth Muscle

SCHMIDLIN, FABIEN, AMADESI, SILVIA, VIDIL, REYNAL, TREVISANI, MARCELLO, MARTINET, NADINE, CAUGHEY, GEORGE, TOGNETTO, MICHELE, CAVALLESCO, GIORGIO, MAPP, CRISTINA, GEPPETTI, PIERANGELO, BUNNETT, NIGEL

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

18

Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment

Olsson, Anders, Nakhlé, Jessica, Sundstedt, Anette, Plas, Pascale, Bauchet, Anne-Laure, Pierron, Valérie, Bruetschy, Luce, Deronic, Adnan, Törngren, Marie, Liberg, David, Schmidlin, Fabien, Leanderson

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

19

Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer

Nakhlé, Jessica, Pierron, Valérie, Bauchet, Anne-Laure, Plas, Pascale, Meyer-Losic, Amath Thiongane Florence, Schmidlin, Fabien

Journal:

Year:

2016

Language:

english

File:

PDF, 3.97 MB

english, 2016

20

Somatostatin receptors in resected hepatocellular carcinoma: status and correlation with markers of poor prognosis

Lequoy, Marie, Desbois-Mouthon, Christèle, Wendum, Dominique, Gupta, Vandana, Blachon, Jean-Luc, Scatton, Olivier, Dumont, Sylvie, Bonnemaire, Mireille, Schmidlin, Fabien, Rosmorduc, Olivier, Fartoux,

Journal:

Year:

2016

Language:

english

File:

PDF, 319 KB

english, 2016

21

Effect of an integrated intervention package of preventive chemotherapy, community-led total sanitation and health education on the prevalence of helminth and intestinal protozoa infections in Côte d’Ivoire

Hürlimann, Eveline, Silué, Kigbafori D., Zouzou, Fabien, Ouattara, Mamadou, Schmidlin, Thomas, Yapi, Richard B., Houngbedji, Clarisse A., Dongo, Kouassi, Kouadio, Bernadette A., Koné, Siaka, Bonfoh, B

Journal:

Parasites & Vectors

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

22

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

Lacraz, Grégory, Giroix, Marie-Hélène, Kassis, Nadim, Coulaud, Josiane, Galinier, Anne, Noll, Christophe, Cornut, Mélanie, Schmidlin, Fabien, Paul, Jean-Louis, Janel, Nathalie, Irminger, Jean-Claude,

Journal:

Year:

2009

Language:

english

File:

PDF, 507 KB

english, 2009

23

Effects of Hygiene and Defecation Behavior on Helminths and Intestinal Protozoa Infections in Taabo, Côte d’Ivoire

Schmidlin, Thomas, Hürlimann, Eveline, Silué, Kigbafori D., Yapi, Richard B., Houngbedji, Clarisse, Kouadio, Bernadette A., Acka-Douabélé, Cinthia A., Kouassi, Dongo, Ouattara, Mamadou, Zouzou, Fabien

Journal:

Year:

2013

Language:

english

File:

PDF, 629 KB

english, 2013

24

The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with β-arrestins

Schmidlin, Fabien, Roosterman, Dirk, Bunnett, Nigel W.

Journal:

AJP Cell Physiology

Year:

2003

Language:

english

File:

PDF, 1.77 MB

english, 2003

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